About the Course

This one week intensive course teaches current approaches in statistical and computational analysis of large-scale experiments in biology, with a focus on DNA sequencing, RNA sequencing and ChIP sequencing. The course also covers the methods for downstream analysis, including statistical testing, machine learning and bioinformatic metadata integration. It is intended for researchers who have a basic familiarity with the experimental technologies and the biology of the genome. The four practical sessions of the course will require basic programming skill in the language R.


  • Introduction to R and Bioconductor
  • RNA-Seq and ChiP-Seq data analysis
  • Statistics for differential expression
  • Manipulation of sequences and genomic intervals
  • Variant calling
  • Annotation of genes, genomic features and variants
  • Gene set enrichment analysis
  • Machine Learning

    Course Structure

    The course consists of
  • 10 lectures of length 90 minutes each: two per day (8:30am - 12:00am), distributed over five consecutive days (Monday to Friday)
  • 4 practical computer tutorials in the afternoons (2pm - 5pm) on Monday, Tuesday, Thursday and Friday.
  • 4 flashlight sessions (5pm to 5:30pm) on Monday, Tuesday, Thursday and Friday.
  • Course Program

    Click here to view the agenda or Download the agenda here

    The course material will be available in electronic form soon after the course.

    Computer Tutorials

    The labs will be worked on in groups with expert guidance (all lecturers from the morning sessions plus teaching assistants).

    Participants are required to bring their own laptops with the most recent release versions of R and Bioconductor installed. A WiFi network card is welcome to connect to our local network - however, no connections to the internet will be possible from the WLAN at the course venue.

    Flashlight Sessions

    In these sessions, course participants will present their current research projects and can receive feedback from other participants and faculty members. Each session has 4 talks of duration 4 min + 2 min discussion each. A total of 16 flashlight presentations will be possible. Selection will be made by the faculty of the course in advance. Please send Wolfgang Huber a "less or equal than" 4 pages PDF file with your slides before 29 June 2012, 17.00h.

    Social Program

    A social activity starts around 2pm on Wednesday and ends in the evening. It will include some mountain walking.

    No Internet Access

    Please note: the course venue will not be able to provide you with internet access. You will be able to connect to a local network that provides the course material.